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Abstract #1146

Novel NMR biomarkers characterizing human knee synovial fluid after ACL-injuries: correlation with immunoassay and longitudinal cartilage MR T1ρ and T2 imaging

Kaipin Xu1, Keiko Amano1, Matthew Tanaka1, Subramaniam Sukumar1, John Kurhanewicz1, Virginia Kraus2, Benjamin Ma1, and Xiaojuan Li1

1University of California, San Francisco, San Francisco, CA, United States, 2Duke University, Durham, NC, United States

Subjects with acute anterior cruciate ligament (ACL) injury have a high risk of developing post-traumatic osteoarthritis (PTOA) even after ACL reconstruction. To identify novel NMR biomarkers of synovial fluid that may predict cartilage degeneration after acute injury and to develop potential preventative strategies for PTOA, human knee synovial fluid harvested from 25 anterior cruciate ligament (ACL) injured subjects were studied using high resolution magic angle spinning (HR-MAS) NMR spectroscopy and correlated to immunoassay and longitudinal cartilage MR T1ρ and T2 imaging.

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