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Abstract #1147

Biomechanical properties of bovine knee cartilage under compressive loading: A study at high field MRI (9.4T) using T1, T2 and T1rho relaxometry combined with DENSE-FID.

Willy Gsell1, Willy Zevenbergen2, Tom Dresselaers1, Deva Chan3, Corey Neu4, Uwe Himmelreich1, and Ilse Jonkers5

1Biomedical MRI group, KU Leuven, Leuven, Belgium, 2Human Movement Biomechanics Research Group, KU Leuven, Leuven, 3Rensselaer Polytechnic Institute, 4Mechanical Engineering, University of Colorado Boulder, 5Human Movement Biomechanics Research Group, KU Leuven

The aim of this study was to correlate the cartilage displacement pattern during cartilage on cartilage contact through displacement encoding imaging during compressive loading with the T1, T2 and T1rho changes, indices of changes in collagen matrix, water and proteoglycan contents. We demonstrated that local mechanical changes in the cartilage during loading were correlated to global molecular changes assessed through T1, T2 and T1rho. The localized cartilage deformation and strain fields suggest a differential response to loading of the different regions of the cartilage which could help in further optimizing cell based therapy for osteoarthritis.

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