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Abstract #1163

Hybrid MR-PET of Brain Tumours with amino acid-PET and Amide Proton Transfer MRI

Nuno André da Silva1, Philipp Lohmann1, James Fairney2,3, Arthur W. Magill1, Ana-Maria Oros-Peusquens1, Chang-Hoon Choi1, Rüdiger Stirnberg 1,4, Xavier Golay2,3, Karl-Josef Langen1,5,6, and N Jon Shah1,7,8

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 4German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 5Jülich Aachen Research Alliance (JARA), Section JARA Brain, Aachen, Germany, 6Department of Nuclear Medicine, RWTH University of Aachen, Aachen, Germany, 7Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, 8Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

Information on amino acid metabolism has become an important component of the diagnostic and prognostic precision in the investigation of brain tumours. Both MRI and PET present methods to obtain amino acid weighted images, such as chemical exchange saturation transfer (CEST) or O-(2-18F- fluoroethyl)-L-tyrosine (FET), respectively. In this work, FET-PET and CEST imaging of brain tumours is investigated using hybrid MR-PET in 8 patients with brain tumours. The results suggest that the tumour-to-brain ratio of magnetization transfer ratio asymmetry (MTRasym) encodes different information than that from FET PET.

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