Abstract #1166

The MRI signature of glial activation: a PET-MRI study using PBR28 radioligand and MR relaxometry

Guillaume Bonnier¹, Tom Hilbert^2,3,4, Daniel Albrecht¹, Marco L. Loggia¹, and Cristina Granziera^1,5

¹MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Siemens Healthcare AG, Advanced Clinical Imaging Technology, Lausanne, Switzerland, ³Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ⁴LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Radioligands used in PET imaging and binding to the translocator protein (TSPO) have proved to be useful to study inflammatory brain processes. Relatedly, quantitative Magnetic Resonance Imaging provides metrics of tissue-level microstructure, which permit to study the consequences of brain inflammation. In this work, we have investigated the relationship between PBR28 radioligant uptake and T1 and T2 metric of brain tissue microstructure based on analysis of PET images, T1 and T2 relaxometry images of 5 HIV subjects.

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