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Abstract #1165

Using simultaneous PET-MRI to investigate the mechanisms of neurodegeneration in frontotemporal dementia

Esther AH Warnert1, Udunna C Anazodo2, Kristy Coleman1, Julia MacKinley1, John Butler2, Frank S Prato2,3, Elizabeth C Finger1, and Keith St. Lawrence2,3

1Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada, 2Lawson Health Research Institute, London, ON, Canada, 3Medical Biophysics, University of Western Ontario, London, ON, Canada

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by progressive degeneration of brain function and structure. We present a proof-of-principle study in which simultaneous PET-MRI is used to inform on the pathophysiology of progressive neurodegeneration. By correlating glucose metabolism (PET) with functional connectivity (MRI), we found altered neuronal signaling in brain regions known to be critical in progression of FTD.

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