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Abstract #1169

Changes in Hippocampal Subfield Volumes, Diffusivity and Brain Metabolism after Electroconvulsive Therapy: a Pilot PET/MR Study

Chuan Huang1,2,3, Laura Kunkel1, Adeeb Yacoub1, Jie Ding3, Christine DeLorenzo1,3, and Ramin Parsey1

1Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 2Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 3Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States

Major depression disorder is a highly prevalent illness with low treatment response rates. Fortunately, electroconvulsive therapy (ECT) is an effective treatment for patients with pharmacotherapy resistant depression, although its mechanism of action remains unclear. There is disagreement regarding the predictive value of amygdala and hippocampal volumes and whether ECT causes neuroplastic effects on these regions in patients with MDD. In this study, we used simultaneous PET/MR to look at structural, diffusion and metabolism changes in brain before and after ECT.

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