Major depression disorder is a highly prevalent illness with low treatment response rates. Fortunately, electroconvulsive therapy (ECT) is an effective treatment for patients with pharmacotherapy resistant depression, although its mechanism of action remains unclear. There is disagreement regarding the predictive value of amygdala and hippocampal volumes and whether ECT causes neuroplastic effects on these regions in patients with MDD. In this study, we used simultaneous PET/MR to look at structural, diffusion and metabolism changes in brain before and after ECT.
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