Abstract #1170

In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s Disease at Ultra-High Magnetic Field compared to Histology

Elisa Tuzzi¹, Gisela Elisabeth Hagberg², David Balla³, Joana Loureiro¹, Manuela Neumann⁴, Christoph Laske⁵, Rolf Pohmann⁶, Matthias Valverde¹, and Klaus Scheffler¹

¹High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ³Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Division of Neuropathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Section for Dementia Research, DE,Hertie-Institute for Clinical Brain Research, Tuebingen, Germany, ⁶High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen

Amyloid-β plaques are classical hallmarks of the post-mortem Alzheimer’s Disease (AD) brain. Ultra-High-Field (UHF) MRI provides a compelling means to investigate pathological processes at an unprecedented level of detail. ß-amyloid plaques can be detected in T2* weighted images at UHF, ex-vivo, due to the local iron content and to the plaque geometry per sè. With this study we aim to explore the source of the observed MR signal changes in AD at UHF using quantitative MRI methods in-vivo and ex-vivo.

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