Abstract #1171

Simultaneous T1, T2 and Diffusion Quantification using Multiple Contrast Prepared Magnetic Resonance Fingerprinting

Yun Jiang¹, Jesse Ian Hamilton¹, Wei-Ching Lo¹, Katherine L. Wright², Dan Ma², Andrew J. Coristine^1,3, Nicole Seiberlich¹, Vikas Gulani^1,2, and Mark A. Griswold^1,2

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, United States, ³Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland

A novel MRF sequence is designed for generating high quality, distortion-free T₁, T₂ and apparent diffusion coefficient (ADC) maps simultaneously in less than 60 seconds per slice. The method inserts multiple magnetization preparation modules in a FISP-based MRF sequence. The use of magnetization preparation modules shortens the preparation time to achieve variable image contrast. Accurate T₁, T₂ and ADC quantification is demonstrated in a phantom and in vivo in human brains. This method enables the simultaneous collection of T₁, T₂ and diffusion maps for tissue characterization without the need to co-register separately acquired maps as in conventional MRI.

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