Abstract #1177

Image-registered whole mount histology technique for validation of MRgFUS therapies

Allison Payne¹, Sara Johnson², Robb Merrill¹, Nicole Winkler¹, Rachel Factor³, and Jill Shea⁴

¹Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ²Bioengineering, University of Utah, Salt Lake City, UT, United States, ³Pathology, University of Utah, Salt Lake City, UT, United States, ⁴Surgery, University of Utah, Salt Lake City, UT, United States

Clinical pathological review of histological samples is the gold standard for identification of tissue damage. For the development of new magnetic resonance-guided focused ultrasound (MRgFUS) procedures, in vivo post-treatment imaging assessment techniques require correlation to histopathology. Our study presents methodology and preliminary preclinical results of a new MRI-registered whole mount histology technique for efficacy evaluation of MRgFUS therapies.

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