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Abstract #1182

Dynamic Spectroscopy of Dissolved-Phase Xenon-129 in the Human Kidney

G. Wilson Miller1, Gordon D. Cates Jr.1,2, David Keder2, Talissa A. Altes3, Jaime F. Mata1, Kun Qing1, Iulian Ruset4, F. William Hersman4, and John P. Mugler III1

1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Physics, University of Virginia, 3Radiology, University of Missouri, 4Xemed LLC

The increase in available dissolved-phase signal made possible by high-performing Xe-129 polarizers has led to renewed interest in dissolved-phase imaging of Xe-129 outside the lung. Here we examine the time course of the dissolved phase Xe-129 signal in the human kidney following gas inhalation, in order to optimize kidney image acquisition and explore the potential for studying kidney function using hyperpolarized Xe-129. In addition to spectral peaks commonly associated with Xe-129 dissolved in tissue/plasma, red blood cells, and fat, we have identified an additional peak at 201 ppm that lags the blood peaks by a few seconds.

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