Abstract #1183

Ventilation Defect Percent in Helium-3 MRI is Associated with Severe Outcomes in Asthma

David Mummy¹, Stanley Kruger¹, Michael Evans², Wei Zha¹, Ronald Sorkness³, Nizar Jarjour⁴, Mark Schiebler⁵, Loren Denlinger⁴, and Sean Fain¹

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Biostatistics & Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States, ³School of Pharmacy, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States

We assessed the ventilation defect percent (VDP) on hyperpolarized helium-3 MRI as an indicator of severe clinical outcomes (emergency department [ED] visits and hospitalizations as surrogates for significant asthma exacerbations). We compared VDP with conventional biomarkers of lung function and inflammation and found VDP was more strongly associated with both ED and hospitalizations as outcomes. VDP was correlated with spirometry, air trapping measured on CT, and eosinophil levels in sputum and peripheral blood. These findings suggest that VDP is a candidate biomarker associated with clinical outcomes of asthma exacerbation and stability.

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