Abstract #1183

Ventilation Defect Percent in Helium-3 MRI is Associated with Severe Outcomes in Asthma

David Mummy¹, Stanley Kruger¹, Michael Evans², Wei Zha¹, Ronald Sorkness³, Nizar Jarjour⁴, Mark Schiebler⁵, Loren Denlinger⁴, and Sean Fain¹

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Biostatistics & Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States, ³School of Pharmacy, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States

We assessed the ventilation defect percent (VDP) on hyperpolarized helium-3 MRI as an indicator of severe clinical outcomes (emergency department [ED] visits and hospitalizations as surrogates for significant asthma exacerbations). We compared VDP with conventional biomarkers of lung function and inflammation and found VDP was more strongly associated with both ED and hospitalizations as outcomes. VDP was correlated with spirometry, air trapping measured on CT, and eosinophil levels in sputum and peripheral blood. These findings suggest that VDP is a candidate biomarker associated with clinical outcomes of asthma exacerbation and stability.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.