Abstract #1184

Regional Detection of Lung Injury using Hyperpolarized Xenon-129 Mapping of Blood Hematocrit in a Rat Model Involving Partial-Lung Irradiation

Brandon Zanette^1,2, Elaine Stirrat¹, Salomeh Jelveh³, Andrew Hope^3,4, and Giles E. Santyr^1,2

¹Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada, ⁴Department of Radiation Oncology, University of Toronto, Toronto, Canada

Dissolved ¹²⁹Xe imaging holds promise for the detection of early functional decline due to radiation-induced lung injury through the extraction of regional quantitative parameters relating to lung physiology and gas exchange. In this work a spiral-IDEAL imaging technique was used with a partial-lung irradiation rat model to investigate regional changes lung function associated with injury and compare to histology. A significant reduction in capillary hematocrit (HCT) was observed in the vicinity of irradiation. These results were in agreement with quantitative histology of red blood cells. Imaging results were more sensitive than whole-lung spectroscopy, which was performed simultaneously.

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