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Abstract #1232

Towards Addressing Unmet Needs in MR-only Radiotherapy Treatment Planning: The Feasibility of Estimating Electron Density from Quantitative Water/Fat Imaging

Abraam S Soliman1,2, Masoud Hashemi2, Alex Karotki2,3, and William Y Song1,2,3

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Radiation Oncology, University of Toronto, ON, Canada

MR-only treatment planning requires the knowledge of electron density to account for medium heterogeneities during dose calculation. This work introduces a novel perspective for electron density estimation by utilizing quantitative water/fat imaging. Water/fat phantoms with different percentages were scanned on MR and CT. Water/fat separation was performed while correcting (or minimizing) major sources of signal bias. A linear regression model between CT and corrected MR signals was calculated and used to derive MR-based electron density curve. This approach targets radiotherapy applications that require sensitive soft-tissue heterogeneity correction such as prostate and breast low-dose-rate (LDR) brachytherapy.

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