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Abstract #1233

A Hyperpolarized 13C MRI Approach for Calculating Glomerular Filtration Rate

Eugene Milshteyn1,2, Cornelius von Morze1, Jeremy W. Gordon1, Galen D. Reed3, Robert A. Bok1, and Daniel B. Vigneron1,2

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF and University of California, Berkeley, San Francisco, CA, United States, 3HeartVista Inc., Los Altos, CA, United States

The feasibility of calculating glomerular filtration rate (GFR) using hyperpolarized 13C MRI is demonstrated in this project. HP001 is exhibited as a potential probe for GFR calculation due to its long T1, allowing for high spatiotemporal resolution, and favorable filtration properties. Multiple iterations of common clinical sequences, including EPI and bSSFP, were utilized, and each sequence yielded GFR values close to those found in literature. The results shown here indicate potential for a new noninvasive imaging measurement of GFR.

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