Abstract #1236

Mapping Abdominal Inflammatory Response Using Manganese-Enhanced MRI (MEMRI)

Kun-Han Lu¹, Jiayue Cao², Lauren Kelly Marussich², Tom C.-C. Hu³, and Zhongming Liu^1,2

¹Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ²Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³Division of CBRN Countermeasures, Biomedical Advanced Research and Development Authority, DC, United States

We used in vivo Manganese-Enhanced MRI (MEMRI) to image and assess the increase in calcium influx into immune cells so as to report the cellular responses to systemically LPS-induced inflammation throughout the abdomen. We found that: (1) The contrast enhancement was dose- and time-dependent with variation across organs. (2) An increase in Mn2+ uptake was observed in the liver and the kidney, but not in the spleen or the muscle given inflammation. (3) The inflammation-induced enhancement was dependent on the time after the initial exposure to LPS.

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