Abstract #1237

Time delay processing of BOLD cerebrovascular reactivity data in patients with moyamoya pre- and post-surgical revascularization reveals a potential new indicator of vascular compliance

Jennifer M Watchmaker¹, Blaise deB Frederick^2,3, Meher R Juttukonda¹, Sarah K Lants¹, Larry T Davis¹, Matthew R Fusco⁴, and Manus J Donahue^1,5,6

¹Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ²Mclean Hospital, Brain Imaging Center, Belmont, MA, United States, ³Department of Psychiatry, Harvard Medical School, Boston, MA, United States, ⁴Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Structural and BOLD-weighted hemodynamic imaging was performed in patients with intracranial steno-occlusion due to moyamoya disease before and after surgical revascularization. A novel data-driven time-delay analysis was performed using cross-correlation of functional imaging data to find the time at which maximum correlation occurs between the BOLD signal from each voxel and a reference regressor. This provides a novel metric of hemodynamic impairment (lagtime) that may be indicative of vascular smooth muscle dysfunction and therefore delayed reactivity. We found that in patients with successful revascularization on angiography, lagtimes decreased, and in patients with unsuccessful revascularization and progressive disease, lagtimes increased.

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