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Abstract #1240

Thalamic functional connectivity in Multiple Sclerosis: the role of temporal thalamic sub-region in maladaptation

Paola Valsasina1, Alessandro D'Ambrosio1, Milagros Hidalgo1, Elisabetta Pagani1, Bruno Colombo2, Mariaemma Rodegher2, Andrea Falini3, Giancarlo Comi2, Massimo Filippi1, and Maria Assunta Rocca1

1Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

We compared resting state (RS) functional connectivity (FC) of five thalamic sub-regions (frontal, motor, post-central, occipital and temporal) between patients with multiple sclerosis (MS) and healthy controls. There was an overall increase of intra- and inter-thalamic RS FC for almost all thalamic sub-regions, apart from the temporal thalamic sub-region, which showed reduced intra-thalamic RS FC and higher RS FC with the fronto-parietal somatomotor cortex. Compared to cognitively preserved, cognitively impaired MS patients had lower RS FC between thalamic sub-regions and caudate nucleus, anterior cingulate cortex, as well as higher RS FC between thalamic sub-regions and several temporal areas.

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