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Abstract #1239

Functional connectivity of DLPFC circuits predicts cocaine relapse

Tianye Zhai1, Hong Gu1, and Yihong Yang1

1Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, United States

TMS targeting the DLPFC has been shown to effectively manipulate inter-temporal behaviors in healthy individuals and drug-using behaviors in cocaine users. However, the neural mechanism through which the DLPFC is involved in the alteration of these behaviors remains unclear. In the current study, we utilized resting-state fMRI to investigate the relationship between the DLPFC functional connectivity and relapse in cocaine addiction. Our voxel-wise Cox regression analyses revealed that two DLPFC circuits have protective effects against cocaine relapse.

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