TMS targeting the DLPFC has been shown to effectively manipulate inter-temporal behaviors in healthy individuals and drug-using behaviors in cocaine users. However, the neural mechanism through which the DLPFC is involved in the alteration of these behaviors remains unclear. In the current study, we utilized resting-state fMRI to investigate the relationship between the DLPFC functional connectivity and relapse in cocaine addiction. Our voxel-wise Cox regression analyses revealed that two DLPFC circuits have protective effects against cocaine relapse.
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