Abstract #1244

Silent Sentence Completion Paradigm Shows Superiority in Localization of Wernicke’s Area and Changes in Functional Activation in the Distinct Language Paradigms Correlate with Key Genomic Markers: A Prospective Study

Kamel El Salek¹, Islam Hassan¹, Scott H Faro², Srishti Abrol ¹, Aikaterini Kotrotsou¹, Feroze B Mohamed², Pascal O Zinn³, Wei Wei⁴, Nan Li⁴, Ashok J Kumar¹, Jeffrey S Weinberg⁵, Jeffrey S Wefel⁶, Shelli R Kesler⁶, Ho-Ling Anthony Liu⁷, Ping Hou⁷, Jason R Stafford⁷, Sujit Prabhu⁵, Raymond Sawaya⁵, and Rivka R Colen^1,8

¹Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, United States, ²Radiology, Temple University, Philadelphia, PA, United States, ³Neurosurgery, Baylor College of Medicine, Houston, TX, United States, ⁴Biostatistics, MD Anderson Cancer Center, Houston, TX, United States, ⁵Neurosurgery, MD Anderson Cancer Center, Houston, TX, United States, ⁶Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, United States, ⁷Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ⁸Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States

The reliability of fMRI for preoperative mapping of language areas depends on the paradigms used, as different tasks harness distinct capabilities to activate areas of speech processing. By comparing 3 language tasks [Silent Sentence Completion (SSC), Category Naming (CAT) and Word Generation (FAS)], we seek to determine the most robust and consistent task in localizing Wernicke’s area. Further the association between genomic markers and functional activation was determined. We included 15 healthy volunteers and 35 patients with gliomas. Results demonstrated that SSC is superior compared to other language paradigms and a correlation exists between tumor genomics and functional activation signals.

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