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Abstract #1245

Altered BOLD fluctuations in gliomas and clinical possibilities

Lalit Gupta1, Rakesh K Gupta2, Prativa Sahoo2, Pradeep K Gupta2, Rana Patir2, Sunita Ahlawat2, Indrajit Saha3, and Walter H Backes1

1Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Fortis Memorial Research Institute, Gurgaon, India, 3Philips India Ltd., Gurgaon, India

In this study, our primary objectives were to characterize the BOLD signal in gliomas using the temporal shift (TS), amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) measures relative to the contralateral cortex, and to analyse the effectiveness of these measures in distinguishing high grade (HGG) from low grade glioma (LGG). Twenty-one patients with HGG and 13 patients with LGG were investigated. Abnormal hemodynamic fluctuations manifest in HGG, but not for LGG, and can be assessed using functional MRI. BOLD measures reflecting TS and ALFF show promise as an alternative to contrast-enhanced perfusion based techniques in future.

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