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Abstract #1246

Improved mapping of epileptic networks based on the correlation of BOLD-fMRI dynamic functional connectivity components with simultaneous EEG

Rodolfo Abreu1, Alberto Leal2, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, 2Department of Neurophysiology, Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal

We propose the use of BOLD dynamic functional connectivity (dFC) analyses to provide further insights into the dynamics of epileptic networks, in simultaneous EEG-fMRI studies. We performed brain parcellation using the AAL atlas and estimated dFC across brain regions using sliding-window correlation. We then tested different approaches for the extraction of functional networks related with the EEG epileptic activity. We found that PCA is a suitable tool to disentangle functional connectivity changes of different origins, and that epilepsy-related networks may be accurately identified based on the correlation of their weights time-courses with metrics of EEG epileptic activity in four patients.

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