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Abstract #1268

Multi-shell neonatal brain HARDI template

Maximilian Pietsch1, Jana Hutter1, Anthony Price1, Maria Kuklisova Murgasova1, Emer Hughes1, Johannes Steinweg2, Nora Tusor2, Jesper Andersson3, Matteo Bastiani4, Stamatios Sotiropoulos3, Joseph V Hajnal1, and J-Donald Tournier1

1Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 2Department of Perinatal Imaging & Health, King's College London, London, United Kingdom, 3FMRIB Centre, University of Oxford, Oxford, United Kingdom, 4Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

We describe a method for creating a group template of the developing brain using advanced multi-shell high angular resolution diffusion (HARDI) data. We decompose the signal into an anisotropic CSF-like and a white matter-like directional component and build an unbiased template of those tissue types from 27 healthy term control babies acquired as part of the Developing Human Connectome Project (gestational age: 40.2+-1.4 weeks). This template will facilitate the analysis of microstructural features at a group level and allow longitudinal investigations into healthy and pathological brain maturation.

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