Abstract #1267

Differentiated maturation of white matter tracts in early developing brain aged 0-3 years

Qinlin Yu^1,2,3,4, Huiying Kang^1,5, Qinmu Peng^1,2, Minhui Ouyang^1,2, Michelle Slinger^1,2, Yun Peng⁵, Fang Fang^3,4, and Hao Huang^1,2

¹Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³School of Psychological and Cognitive Sciences, Peking University, Beijing, People's Republic of China, ⁴Peking-Tsinghua Center for Life Science, Peking University, Beijing, People's Republic of China, ⁵Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, People's Republic of China

The brain development in the first several years after birth is perhaps most dynamic. However, the studies on white matter maturation of infants and toddlers with relatively evenly distributed ages in 0-3 years are rare. Here, we charted white matter development in subjects 0-3 years-of-age through measurements of DTI-derived metrics at the tract level and tract-group level. A 3-stage maturational pattern was revealed for all white matter tracts. The differentiated maturation among the white matter tracts and tract groups was found using DTI measurements.

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