Previous studies have shown that measures of non-Gaussian diffusion from diffusion kurtosis images (DKI) provide unique information on age-related tissue changes. In this study, a novel non-Gaussian diffusion index invariant to the distribution of fibres is proposed and applied to 650 datasets from the Cam-CAN ageing project. The results show that the proposed biomarker is not only applicable to any tissue configuration but also less sensitive to noise and artefacts when compared to traditional DKI measures. Moreover, for white matter regions, age-related changes measured by this index seem to reflect axonal alterations likely related to axonal loss mechanisms.
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