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Abstract #1280

Subject-specific 3D Modeling of Macaque Brain via Automatic Tissue Registration Based on in vivo MR Images Acquired at 7T

Weidao Chen1,2, Bo Peng3, Yi Sun4, Gang Chen1,2, Anna Wang Roe1,2, Yakang Dai3, and Xiaotong Zhang1,2

1Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou, People's Republic of China, 2College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, People's Republic of China, 3Medical Imaging Department, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, People's Republic of China, 4MR Collaboration Northeast Asia, Siemens Healthcare, Shanghai, People's Republic of China

Accurate subject-specific 3D modeling of macaque brain with anatomical subdivisions is important for neuroscience, neurophysiology and engineering researches. In this study, we have proposed a feasible approach for automatically creating 3D models of macaque brain based on in vivo MR images. A 3D template of macaque brain, consisting of scalp, skull, grey matter, white matter, and cerebrospinal fluid, was firstly constructed from 7T T1w images over an anesthetized macaque; then, by implementing symmetric feature-based pairwise registration method, this template was used to register another in vivo 7T dataset of macaque brain, which enables automatic and subject-specific 3D macaque brain modeling.

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