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Abstract #1383

Validation of MRE measurements of shear modulus in both annulus fibrosus and nucleus pulposus within in two animal species

Delphine Perie1,2, Lauriane Jugé3, Alexandra Mlodzinski1, and Lynne Bilston3

1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Research Center, Sainte-Justine Hospital, Montreal, QC, Canada, 3NeuRA, Sydney, Australia

Magnetic resonance elastography (MRE) is an effective method to measure the shear modulus of the nucleus pulposus, and its changes with degenerescence. However, MRE was not used for the annulus fibrosus. This study validated the use of MRE for the measurements of the shear modulus variations within the intervertebral discs between regions (annulus fibrosus versus nucleus pulposus) and animal species (bovine versus kangaroo). Shear dynamic mechanical tests and MRE showed equivalent tissue differences. This study also highlighted that the loading history of the intervertebral disc has to be considered when choosing an animal model.

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