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Abstract #1385

Optimal spatial resolution for accuracy and precision in simulated and experimental micro-MRE at 11.7 T

Felicia Julea1, Jin Long Yue1, Tanguy Boucneau1, Marion Tardieu2, Benoit Larrat3, Claire Pellot-Barakat4, and Xavier Maître1

1Imagerie par Résonance Magnétique Médicale et Multi-Modalités, IR4M, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France, 2Centre de Recherche sur l’Inflammation, CRI, Inserm, CNRS, Univ. Pierre et Marie Curie, Paris, France, 3Unité d’Imagerie par Résonance Magnétique et Spectroscopie, NeuroSpin, I2BM, DRF, CEA, Gif Sur Yvette, France, 4Imagerie Moléculaire In Vivo, IMIV, Inserm, CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France

MRE outcomes depend on various factors, which include SNR, spatial resolution, mechanical frequency, induced shear wave amplitude, and reconstruction method. It was formerly shown in a simulation study that 7 to 10 voxels were needed to properly resolve the shear wavelength, λref, and both accurately and precisely quantify the mechanical properties of the targeted tissue by inversion of the equation of motion. The purpose here is to experimentally reproduce the conditions defined by the simulation to determine the actual influence of the acquisition voxel size, a, on MRE acquisitions and validate the predicted λref/a conditions for optimal MRE reconstruction.

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