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Abstract #1386

Alteration of mechanical tissue parameters during progressive formalin fixation measured by broadband Magnetic Resonance Elastography using a compact and portable tabletop scanner

Jürgen Braun1, Heiko Tzschätzsch2, Clara Körting3, Marika Jenderka3, Angela Ariza de Schellenberger2, Toni Drießle4, Michael Ledwig4, and Ingolf Sack2

1Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Beuth Hochschule für Technik Berlin, Berlin, Germany, 4Pure Devices GmbH, Würzburg, Germany

A compact tabletop MR elastography (MRE) device was employed for rheological tests of soft tissue samples to measure the change of viscoelastic powerlaw constants in liver and brain tissue during progressive fixation. Shear-modulus dispersion functions were acquired from 300 to 5700Hz in animal tissues at different states of formaldehyde fixation and fitted by the rheological springpot-powerlaw model. Formalin fixation reduced viscosity and increased elasticity of liver tissue faster and to a higher degree than in brain tissue similar to the alteration of mechanical properties observed by in vivo elastography of hepatic fibrogenesis.

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