Unexpected phase errors occurred in the k-space of the diffusion spectrum EPI sequence would lead to abrupt shifts in the phase-encoding direction across different diffusion gradient directions which cause shaking artifact of the image. The shaking artifact can lead to errors in image registration and diffusion index calculation. Here, we developed an estimated maximum likelihood method to detect and correct image shifts. After correcting the shaking artifact, the performance of registration and the diffusion index calculation were significantly improved comparing to the images without correction.
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