In this study we investigate possible benefits of an application of ‘AWESOME’ de-noising on fMRI. The application in a high-SNR finger tapping experiment showed a reduction of the already low thermal noise contribution and therefore improvement of tSNR and reduction of false positives; no adverse effects in the form of smoothing or suppression of ‘true’ activation was observed. A second investigation of the scalability of tSNR improvement on a resting state experiment with variable slice thickness / SNR showed that thermal noise can be reliably reduced and the tSNR proportionally improved without visible reduction of detail sharpness / resolution.
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