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Abstract #1463

Assessment of interplatform reproducibility of T1 quantification methods used for DCE-MRI: results from a multicenter phantom study

Octavia Bane1, Stefanie Hectors1, Mathilde Wagner1,2, Lori R Arlinghaus3, Madhava Aryal4, Michael Boss5, Yue Cao4, Thomas L Chenevert6, Fiona Fennessy7, Wei Huang8, Nola Hylton9, Jayashree Kalpathy-Cramer10, Kathryn E Keenan5, Dariya Malyarenko6, Robert Mulkern7, David Newitt9, Karl F Stupic5, Lisa Wilmes9, Thomas Yankeelov11, Yi-Fen Yen10, Stephen E Russek5, and Bachir Taouli1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Radiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 3Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 4Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, 5Physical Measurement Laboratory, National Institute of Standards and Technology (NIST), Boulder, CO, United States, 6Radiology, University of Michigan, Ann Arbor, MI, United States, 7Radiology, Brigham and Women's Hospital, Boston, MA, United States, 8Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 9Radiology, University of California San Francisco Mount Zion Hospital, San Francisco, CA, United States, 10Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 11Biomedical Engineering, University of Texas at Austin, Austin, TX, United States

Our multicenter study examined variability in T1 quantification by testing common inversion-recovery spin echo and variable flip angle (VFA) protocols, as well as T1 mapping methods used by participating sites, using a phantom with known T1 values. We found field strength dependence of the accuracy, and platform dependence of the repeatability of T1 measurements with the common VFA protocol. Accuracy for site-specific protocols was influenced by site, while repeatability, by type of protocol. Our findings suggest modified IR methods and VFA protocols with multiple flip angles and B1 correction as good methods for repeatable T1 measurement.

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