Abstract #1463

Assessment of interplatform reproducibility of T1 quantification methods used for DCE-MRI: results from a multicenter phantom study

Octavia Bane¹, Stefanie Hectors¹, Mathilde Wagner^1,2, Lori R Arlinghaus³, Madhava Aryal⁴, Michael Boss⁵, Yue Cao⁴, Thomas L Chenevert⁶, Fiona Fennessy⁷, Wei Huang⁸, Nola Hylton⁹, Jayashree Kalpathy-Cramer¹⁰, Kathryn E Keenan⁵, Dariya Malyarenko⁶, Robert Mulkern⁷, David Newitt⁹, Karl F Stupic⁵, Lisa Wilmes⁹, Thomas Yankeelov¹¹, Yi-Fen Yen¹⁰, Stephen E Russek⁵, and Bachir Taouli¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Radiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, ³Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, ⁵Physical Measurement Laboratory, National Institute of Standards and Technology (NIST), Boulder, CO, United States, ⁶Radiology, University of Michigan, Ann Arbor, MI, United States, ⁷Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁸Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ⁹Radiology, University of California San Francisco Mount Zion Hospital, San Francisco, CA, United States, ¹⁰Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ¹¹Biomedical Engineering, University of Texas at Austin, Austin, TX, United States

Our multicenter study examined variability in T₁ quantification by testing common inversion-recovery spin echo and variable flip angle (VFA) protocols, as well as T₁ mapping methods used by participating sites, using a phantom with known T₁values. We found field strength dependence of the accuracy, and platform dependence of the repeatability of T₁ measurements with the common VFA protocol. Accuracy for site-specific protocols was influenced by site, while repeatability, by type of protocol. Our findings suggest modified IR methods and VFA protocols with multiple flip angles and B₁ correction as good methods for repeatable T₁ measurement.

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