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Abstract #1492

On the Influence of Intra-Voxel Dephasing in FISP-MRF with Variable Repetition Time

Sebastian Flassbeck1, Simon Schmidt1, Mathies Breithaupt1,2, Peter Bachert1, Mark E. Ladd1, and Sebastian Schmitter1,3

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute for Forensic Medicine and Traffic Medicine, 3Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

In this work we investigate the impact of intra-voxel dephasing on standard FISP-MRF measurements and propose the use of a constant TR to improve the robustness against spatially changing magnetic fields. The results have shown that FISP MRF measurements with a variable TR are susceptible to intra-voxel dephasing, which may generate temporal signal modulations that are likely to cause quantification errors in relaxation parameters. This can be alleviated by fixing TR without loss of encoding capability.

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