Abstract #1492

On the Influence of Intra-Voxel Dephasing in FISP-MRF with Variable Repetition Time

Sebastian Flassbeck¹, Simon Schmidt¹, Mathies Breithaupt^1,2, Peter Bachert¹, Mark E. Ladd¹, and Sebastian Schmitter^1,3

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Institute for Forensic Medicine and Traffic Medicine, ³Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

In this work we investigate the impact of intra-voxel dephasing on standard FISP-MRF measurements and propose the use of a constant TR to improve the robustness against spatially changing magnetic fields. The results have shown that FISP MRF measurements with a variable TR are susceptible to intra-voxel dephasing, which may generate temporal signal modulations that are likely to cause quantification errors in relaxation parameters. This can be alleviated by fixing TR without loss of encoding capability.

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