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Abstract #1495

Rapid background magnetic field inhomogeneity correction in MR-based oxygen imaging

Yasheng Chen1, Xiaodong Zhang2, Cihat Eldeniz3, Dustin Ragan1, Liam Comiskey1, Melanie Fields4, Kristin Guilliams1, Jin-Moo Lee1, Andria Ford1, and Hongyu An3

1Neurology, Washington Univ. in St. Louis, St. Louis, MO, United States, 2Radiology, Peking University Hospital, Beijing, People's Republic of China, 3Radiology, Washington Univ. in St. Louis, St. Louis, MO, United States, 4Pediatrics, Washington Univ. in St. Louis, St. Louis, MO, United States

Quantitative blood oxygenation level dependent (qBOLD) technique provides an invaluable and noninvasive means for mapping brain oxygen extraction fraction (OEF) and R2’ in various neurological disorders. However, background magnetic field inhomogeneity causes errors in the measurement. In this work, we propose a triple echo asymmetric spin echo sequence with imbedded Z-shimming table to measure and correct the adversary effect of the field inhomogeneity. With both simulation and 16 patient image sets, we have demonstrated the effectiveness of the proposed technique.

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