Abstract #1495

Rapid background magnetic field inhomogeneity correction in MR-based oxygen imaging

Yasheng Chen¹, Xiaodong Zhang², Cihat Eldeniz³, Dustin Ragan¹, Liam Comiskey¹, Melanie Fields⁴, Kristin Guilliams¹, Jin-Moo Lee¹, Andria Ford¹, and Hongyu An³

¹Neurology, Washington Univ. in St. Louis, St. Louis, MO, United States, ²Radiology, Peking University Hospital, Beijing, People's Republic of China, ³Radiology, Washington Univ. in St. Louis, St. Louis, MO, United States, ⁴Pediatrics, Washington Univ. in St. Louis, St. Louis, MO, United States

Quantitative blood oxygenation level dependent (qBOLD) technique provides an invaluable and noninvasive means for mapping brain oxygen extraction fraction (OEF) and R2’ in various neurological disorders. However, background magnetic field inhomogeneity causes errors in the measurement. In this work, we propose a triple echo asymmetric spin echo sequence with imbedded Z-shimming table to measure and correct the adversary effect of the field inhomogeneity. With both simulation and 16 patient image sets, we have demonstrated the effectiveness of the proposed technique.

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