Abstract #1496

Improving Arterial Spin Labeling Acquisition to Reduce the Effect of Delayed Arrival Time

Andre Monteiro Paschoal¹, Renata Ferranti Leoni¹, Antonio Carlos dos Santos², Bernd Uwe Foerster, and Fernando Fernandes Paiva³

¹Physics Department, University of Sao Paulo, Ribeirao Preto, Brazil, ²Internal medicine, Medical School of Ribeirao Preto, Ribeirao Preto, Brazil, ³Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil

Arterial Spin Labeling (ASL) is a powerful technique to evaluate cerebral blood flow. To analyze hemodynamics effects with ASL, multiples acquisitions over the time are realized, which is called multiphase ASL. In conventional multiphase ASL methods, the later phases has low contrast to noise ratio, so it becomes difficult to analyze it. This study purposes a solution to this problem, through a modulation in the acquisition flip angle. With this technique, the flip angle of all phases follows a modulation equation, so that the ASL signal over the phases becomes nearly constant.

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