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Abstract #1534

MR Microscopy of early changes in osteoarthritis – Ex-vivo study of the osteochondral degenerative process at 7T

Benedikt Hager1,2, Sonja Walzer3, Vladimir Juras1,4, Martin Zalaudek1, Xeni Deligianni5, Oliver Bieri5, Andreas Berg6, Joachim Friske1, Reinhard Windhager3, and Siegfried Trattnig1,2

1High Field MR Centre, Department of Biomedical Imgaing and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 6Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

Visualizing the early changes in osteoarthritis is still challenging the musculoskeletal imaging community. Especially structures of the osteochondral junction cannot be depicted by conventional MRI due to their thinness and short T2/T2* relaxation times. A variable echo time sequence in combination with high field 7T and a MR microscopy setup, allows microscopic resolution and echo times in the sub-millisecond range and can be used for visualizing short T2/T2* structures of the cartilage-bone interface such as calcified cartilage. In this study we focused on imaging early changes in osteoarthritis as approach for bringing biological information closer to clinic related applications.

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