Abstract #1534

MR Microscopy of early changes in osteoarthritis – Ex-vivo study of the osteochondral degenerative process at 7T

Benedikt Hager^1,2, Sonja Walzer³, Vladimir Juras^1,4, Martin Zalaudek¹, Xeni Deligianni⁵, Oliver Bieri⁵, Andreas Berg⁶, Joachim Friske¹, Reinhard Windhager³, and Siegfried Trattnig^1,2

¹High Field MR Centre, Department of Biomedical Imgaing and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, ⁶Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

Visualizing the early changes in osteoarthritis is still challenging the musculoskeletal imaging community. Especially structures of the osteochondral junction cannot be depicted by conventional MRI due to their thinness and short T2/T2* relaxation times. A variable echo time sequence in combination with high field 7T and a MR microscopy setup, allows microscopic resolution and echo times in the sub-millisecond range and can be used for visualizing short T2/T2* structures of the cartilage-bone interface such as calcified cartilage. In this study we focused on imaging early changes in osteoarthritis as approach for bringing biological information closer to clinic related applications.

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