Meeting Banner
Abstract #1536

The effect of loading on ultrashort echo time magnetization transfer (UTE-MT) imaging and modelling parameters in human articular cartilage: a feasibility study

Saeed Jerban1, Ma Yajun1, Michael Carl2, Xin Cheng1, Eric Y Chang1,3, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

UTE_MRI is assumed to be a great non-invasive technique to assess articular cartilage (AC) as a unique viscoelastic tissue, with a very short T2. Early stage of cartilage osteoarthrosis, is hypothesized to affect the mechanical properties of AC, sooner and quicker than its morphology. This study, focused on the application of the UTE_MT modelling and MT ratio variations in femorotibial AC in loaded knee. Compressing the cadaveric human intact knee with different loads, using an MRI-compatible device, resulted in significant increases macromolecule fraction. The local MTR maxima in the AC were interestingly shifted towards the contact point after loading.

This abstract and the presentation materials are available to members only; a login is required.

Join Here