UTE_MRI is assumed to be a great non-invasive technique to assess articular cartilage (AC) as a unique viscoelastic tissue, with a very short T2. Early stage of cartilage osteoarthrosis, is hypothesized to affect the mechanical properties of AC, sooner and quicker than its morphology. This study, focused on the application of the UTE_MT modelling and MT ratio variations in femorotibial AC in loaded knee. Compressing the cadaveric human intact knee with different loads, using an MRI-compatible device, resulted in significant increases macromolecule fraction. The local MTR maxima in the AC were interestingly shifted towards the contact point after loading.