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Abstract #1542

Multiparametric MRI assessment reveals early cartilage degeneration at 2 and 8 weeks after anterior cruciate ligament transection in a rabbit model

Victor C. Casula1,2, Abdul Wahed Kajabi1,2, Simo Ojanen1,3, Mikko Finnilä1,3, Rami Korhonen3,4, Walter Herzog5, Simo Saarakkala1,2, Mikko J. Nissi3,4, and Miika T. Nieminen1,2,6

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, 6Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

The sensitivity of several quantitative MRI parameters to early degenerative changes in articular cartilage was investigated in an experimentally induced anterior cruciate ligament transection (ACLT) rabbit model. Namely T1, continuous wave T1ρ (CWT1ρ), adiabatic T1ρ (AdT1ρ) and T2ρ (AdT2ρ), T2 and TRAFF (relaxation along a fictitious field) were measured at 9.4 T. All parameters showed significant elongation within two weeks of ACLT, except TRAFF. Rotating frame parameters showed some evidence of superior sensitivity to cartilage alterations. A multiparametric approach may enhance the discrimination power of quantitative MRI for early cartilage degeneration.

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