Abstract #1542

Multiparametric MRI assessment reveals early cartilage degeneration at 2 and 8 weeks after anterior cruciate ligament transection in a rabbit model

Victor C. Casula^1,2, Abdul Wahed Kajabi^1,2, Simo Ojanen^1,3, Mikko Finnilä^1,3, Rami Korhonen^3,4, Walter Herzog⁵, Simo Saarakkala^1,2, Mikko J. Nissi^3,4, and Miika T. Nieminen^1,2,6

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ³Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ⁴Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁵Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, ⁶Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

The sensitivity of several quantitative MRI parameters to early degenerative changes in articular cartilage was investigated in an experimentally induced anterior cruciate ligament transection (ACLT) rabbit model. Namely T₁, continuous wave T_1ρ (CWT_1ρ), adiabatic T_1ρ (AdT_1ρ) and T_2ρ (AdT_2ρ), T₂ and T_RAFF (relaxation along a fictitious field) were measured at 9.4 T. All parameters showed significant elongation within two weeks of ACLT, except T_RAFF. Rotating frame parameters showed some evidence of superior sensitivity to cartilage alterations. A multiparametric approach may enhance the discrimination power of quantitative MRI for early cartilage degeneration.

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