Abstract #1541

Correlation time mapping of articular cartilage degeneration in equine model

Abdul Wahed Kajabi^1,2, Mikko J. Nissi^3,4, Juuso Ketola², Jaakko K. Sarin³, Victor Casula^1,2, Juha Töyräs^3,4, René Van Weeren⁵, Harold Brommer⁵, Jos Malda^5,6, Irina A.D. Mancini⁵, Matti Hanni^1,2,7, and Miika T. Nieminen^1,2,7

¹Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ²Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ³Department of Applied Physics, University of Eestern Finland, Kuopio, Finland, ⁴Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁵Department of Equine Sciences, Utrecht University, Netherlands, ⁶Department of Orthopaedics, University Medical Center Utrecht, Netherlands, ⁷Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Correlation time mapping was utilized to study structural alterations in articular cartilage of the femoral trochlea harvested from skeletally mature equines. Samples originated from a study in which surgically created lesions in the lateral trochlear ridge of the femur were filled with different materials and were left to heal for 12 months. Correlation time maps of the cartilage or repaired tissues were obtained from fitting T_1ρ relaxation dispersion data. The correlation times of the repair tissue from the lesion site and tissue next to the lesion site were significantly shorter than the correlation times in a location distant from the lesion, indicating gradual degenerative changes observed in early osteoarthritis.

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