Abstract #1546

T1ρ assessment of cartilage in a large animal model of traumatic joint injury

Daniel Thedens¹, David Heckelsmiller², Barbara Laughlin², Mothana Saad Eldine², Douglas Pedersen², Douglas Fredericks², and Jessica Goetz²

¹Radiology, University of Iowa, Iowa City, IA, United States, ²Orthopedics & Rehabilitation, University of Iowa, Iowa City, IA, United States

MRI offers the opportunity for early characterization of cartilage in injured joints with emerging contrast mechanisms such as T1ρ. The purpose of this work was to investigate the ability of T1ρ to detect early cartilage changes in a large animal (goat) model of PTOA. T1ρ imaging of injured joints showed increased relaxation times six months after injury compared to uninjured contralateral joints in five animals. T1ρ may help better elucidate the time course and mechanisms of cartilage degeneration in PTOA.

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