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Abstract #1547

Biomechanical T2-mapping in osteoarthritis with 3D-TESS at 7T MRI

Sebastian Roehrich1, Pavol Szomolanyi1, Markus Schreiner2, Vladimir Juras1, Rahel Heule3, Oliver Bieri3, and Siegfried Trattnig1,4

1Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria, 2Department of Orthopedic Surgery, Medical University of Vienna, Vienna, Austria, 3Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 4Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Biochemical MRI of hyaline cartilage shows promising results for the evaluation of OA. In this study we implemented in-vivo compression and a fast 3D-TESS sequence at 7T for cartilage transversal relaxation time (T2)-mapping of healthy volunteers and patients with risk factors for the development of early osteoarthritis of the knee (OA). Results show a location-dependent and differing behavior of T2-values under compression between the two groups, further increasing the value of T2-values as possible biomarker for OA.

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