In this study, we demonstrated the feasibility of in-vivo biexponential T1ρ and T2 relaxation measurement of knee articular cartilage using 3T MRI in clinically feasible scan times in eight healthy volunteers. Our preliminary results demonstrate that the biexponential model better represents the relaxation behavior in articular cartilage and can be used to distinguish different water compartments associated with macromolecules (tightly bound and loosely bound water) in the cartilage.
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