This study presents both an analysis pipeline for measuring diaphragmatic motion from cine MRI data, and the application of this image processing technique to investigate exploratory MRI endpoints of respiratory function in both healthy controls and non-ambulant DMD boys. Cine-derived metrics of diaphragm motility and contractility correlated with sitting spirometry-derived forced vital capacity, and showed relationships with disease progression surrogates of age and months non-ambulatory, as well as a longitudinal change over 12 months. Longitudinal changes were not seen in spirometry measures.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords