Abstract #1564

Noninvasive MRI Biomarkers for Muscular Dystrophy Progression in Young Muscle

Joshua S Park¹, Ravneet Vohra¹, Thomas Klussmann^1,2, Niclas Bengtsson^3,4, Jeffrey Chamberlain^2,3,4,5, and Donghoon Lee¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Biochemistry, University of Washington, Seattle, WA, United States, ³Neurology, University of Washington, Seattle, WA, United States, ⁴Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington, Seattle, WA, United States, ⁵Medicine, University of Washington, Seattle, WA, United States

Muscular dystrophy is a family of inherited diseases characterized by progressive muscle weakness that leads to muscle damage and wasting, and in the case of Duchenne muscular dystrophy (DMD), is fatal. Clinical measures of muscular dystrophy rely on surgical biopsy, which is invasive and provides a limited overview of the disease’s progression. Magnetic resonance imaging (MRI) may provide valuable information pertaining to tissue characteristics of this disease. We performed multi-parametric MRI to assess the changes in young dystrophic mice. The changes observed in skeletal muscles demonstrate MRI parameters may be used to track disease progression and future treatment options.

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