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Abstract #1573

Targeted modulation of retinoid signaling using polymeric nanoparticles in a mouse model of Amyotrophic Lateral Sclerosis

David Medina1, Eugene Chung1, Ricki Ceton1, Robert Bowser1, Rachael Sirianni1, and Gregory Turner2

1Neurobiology, Barrow Neurological Institute, Phoenix, AZ, United States, 2Research Imaging, Barrow Neurological Institute, Phoenix, AZ, United States

Retinoid signaling activity in the CNS, mediated by RARβ, directly influences ALS pathology development and progression in vivo and CNS targeted delivery of RARβ agonists can reduce ALS pathology in vivo when delivered systemically via polymeric nanoparticles. In this study the therapeutic affect of adapalene, a RARβ agonist, loaded nanoparticles were examined by measuring quadriceps volume in a SOD1G93A mouse model of ALS.

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