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Abstract #1579

A Potential Pathophysiological Link Between Generalized and Localized Muscle Fat Infiltration in Chronic Whiplash Patients

Anette Karlsson1,2, Anneli Peolsson3, James Elliott4, Thobias Romu1,2, Helena Ljunggren3, and Olof Dahlqvist Leinhard2,5

1Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, 3Department of Medical and Health Sciences, Physiotherapy, Linköping University, Linköping, Sweden, 4Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 5Department of Medical and Health Sciences, Linköping University, Linköping, Sweden

Muscle fat infiltration (MFI) in the cervical multifidi muscles and whole-body skeletal muscle tissue was measured in participants with chronic whiplash associated disorders (WAD) using whole-body fat-water separated MRI to investigate potential interaction between deep neck muscle and generalized MFI. Thirty participants with chronic WAD and 30 matched controls were included. MFI in multifidi was strongly associated to whole-body MFI as well as to severity of WAD. The strong association between Multifidi MFI and whole-body MFI indicates that both generalized factors and localized effects related to the trauma may be important for understanding the pathophysiology of chronic WAD.

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