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Abstract #1599

Non-Gaussian water diffusion kurtosis imaging and T2* mapping of Intervertebral Disc Degeneration at 3T MR

Feifei Zeng1, Yun fei Zha1, Dong Xing1, Liang Li1, and Hui Lin2

1Radiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China, 2GE healthcare China

To assess the feasibility of detecting early biochemical changes of nucleus pulposus (NP) in intervertebral disk degeneration (IVDD) by diffusion kurtosis imaging (DKI), and compare mean kurtosis (MK) and T2* mapping in IVDD according to Pfirrmann grades. Twenty individuals underwent lumbar sagittal T2-weighted image, DKI and T2* mapping. DKI related parameters—mean kurtosis (MK) and T2* values were measured. The differences between MK and T2* value in NP were highly significant. Pfirrmann grades were inversely significantly correlated with T2* values in the NP, and positively correlated with MK values, especially between Pfirrmann grade II ,III and Ⅳ.

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