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Abstract #1602

Intervertebral disc heterogeneity decoded with MRI histogram analysis

Christian Waldenberg1,2, Hanna Hebelka2,3, Helena Brisby2,4, and Kerstin Magdalena Lagerstrand1,2

1Dept. of Medical Physics and Techniques, Sahlgrenska University Hospital, Gothenburg, Sweden, Sahlgrenska University Hospital, Gothenburg, Sweden, 2Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 3Dept of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden, 4Dept of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden

Low back pain has major consequences for both the individual as well as for the society which often results in sick leave from work. Unfortunately, health care today lacks diagnostic techniques and procedures necessary to select and treat patients who would most benefit from treatment. Histogram analysis based on MRI imaging has the potential to display disc heterogeneity and possibly depict painful discs. A total of 98 histograms of 49 intervertebral discs were generated based on three mid-sagittal slices of high quality T2W MRI images and T2-maps. Using MATLAB, a two component Gaussian mixture distribution model was fitted to the histogram data in order to retrieve disc heterogeneity measures. Mann-Whitney U-test displayed a significant difference in disc heterogeneity measures with increased Pfirrmann grade.

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