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Abstract #1615

Application of lower extremity oxygenation imaging in animal model of microsphere-induced femoral artery embolization

Chengyan Wang1, Haochen Wang2, Bihui Zhang2, Rui Zhang3, Xiaodong Zhang4, Min Yang2, Jue Zhang1,3, Xiaoying Wang1,4, and Jing Fang1,3

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, 2interventional radiology and vascular surgery, Peking University First Hospital, Beijing, People's Republic of China, 3College of Engineering, Peking University, Beijing, People's Republic of China, 4Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China

Embolization following percutaneous intervention is a universal problem occurring in all vascular beds, especially in lower extremities. This study assesses the performance of a noninvasive MRI based oxygenation imaging, in characterizing muscle oxygen extraction fraction (OEF) level after microsphere-induced lower extremity embolization in animal models. By comparison of the calculated muscle OEFs and R2’ before and after surgery, significantly increase could be found. The results show promise in the evaluation of early muscle ischemia in many clinical diseases such as acute lower limb embolism or peripheral artery disease.

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