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Abstract #1622

In vivo assessment of trabecular bone in the proximal femur

Maria Kalimeri1, Christiani Jeyakumar Henry2, Su Xiao Di3, Marlena C Kruger4, and John James Totman5

1A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore, 2Clinical Nutrition Research Centre, Singapore, Singapore, 3Institute of Materials Research and Engineering, Singapore, Singapore, 4School of Food and Nutrition, Massey Institute of Food Science and Nutrition, Massey University, New Zealand, 5Diagnostic Radiology, A-STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore

Osteoporosis is a bone disease that predominately affects postmenopausal women. Routine screening of osteoporosis is performed by means of Dual X-ray Absorptiometry (DXA) which is limited by its inability to differentiate between cortical and trabecular bone, reduced accuracy due to overlying tissue and the use of ionising radiation. In this abstract, we investigate the use of MRI as an alternative, in a cohort of 95 Chinese-Singaporean postmenopausal women. Strong correlations with DXA measurements were observed, in addition to significant differences between the normal and osteopenic, normal and osteoporotic groups.

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