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Abstract #1635

Mu opioid receptor activation signatures on brain activity and connectivity by fMRI in mice

Md Taufiq Nasseef1, Emmanuel Darcq1, Praveen Kulkarni2, and Brigitte L. Kieffer1

1Department of Psychiatry, Douglas Mental Health University Institute, Montreal, QC, Canada, 2Center for Translational Neuro-Imaging, Northeastern University, Boston, MA, United States

Mu opioid receptors (MORs) mediate the strong analgesic and rewarding effects of morphine. We used non-invasive imaging fMRI in wild-type and MOR knockout mice to assess MOR-dependent effects at the scale of the whole brain. Here, we present striatum seed-based signatures identified by BOLD activation map, functional connectivity and directionality. We identified MOR-specific activation of the striatum between 2 and 7 minutes after morphine administration. Furthermore, during this time interval, the brain connectivity was altered by morphine in wild type but not mutant mice. This is the first reported on-target morphine activation signature in the striatum of live animals.

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